A Case of Disseminated Herpes Zoster With Polyneuropathy Following the Third Dose of the Pfizer-BioNTech Vaccine.

SARS-CoV-2 pandemic resulted in the fast development of new vaccines, which helped contain the pandemic, but some adverse events started to rise. Recently, post-administration of mRNA-based vaccines, varicella-zoster virus (VZV) reactivation was reported. We report a case of disseminated herpes zoster with polyneuropathy and cerebrospinal fluid (CSF) findings following the Pfizer-BioNTechvaccine. Our observation aims to increase clinicians' awareness of a possible relationship between herpes zoster reactivation and SARS-CoV-2 vaccines.

Changing Food Patterns during the Pandemic: Exploring the Role of Household Dynamics and Income Stabilization Strategies

COVID-19 still looms as the largest risk to the agriculture, energy, and health sectors, threatening sustainable global economic development. The literature shows that the COVID-19 pandemic can divert governments' attention away from climate change, renewable energy, and food security challenges that are necessary to address for sustainable economic growth. The COVID-19 pandemic has consistently influenced environmental behaviors, as it has primarily decreased income levels and disrupted food systems worldwide. This study examined the impacts of COVID-19 on food consumption patterns, food diversity, and income challenges and explored the factors affecting food consumption patterns during the pandemic. The data collected through an online survey from 1537 Chinese households were analyzed through a paired t-test, a mixed-design ANOVA, and a logistic regression analysis. The results revealed that the consumption of the majority of individual food commodities decreased during the COVID-19 pandemic. Among the individual food items, the consumption of pork witnessed the greatest decrease during the COVID-19 pandemic compared to the normal period. The decrease in food diversity was higher for the households whose income was affected compared to the households whose income was not affected during the COVID-19 pandemic. Furthermore, the consumption quantities of various food groups declined more for highly income-affected households than for medium and slightly affected households during the pandemic. Households that adopted a dissaving income-stabilizing strategy were 47% points more likely to maintain their food consumption patterns during the pandemic. Farmers were 17% points and 19% points less likely to suffer worsened food consumption compared to self-employed and wage workers, respectively, during the pandemic. Thus, self-production methods such as kitchen gardening can assist households to maintain and improve their consumption of food commodities during the COVID-19 pandemic. © 2022 by the authors.

Clinical Characteristics of Novel Coronavirus Disease in the Pediatric Population

Objective: To assess the clinical characteristics of COVID-19 Virus disease in the pediatric population in Pakistan. Study Design: Cross-sectional study. Place and Duration of Study: Pak Emirates Military Hospital, Rawalpindi Pakistan, from Mar 2020 to Jan 2021. Methodology: All children presenting to the department with symptoms consistent with COVID-19 disease were tested for the virus. Patients who tested positive on the PCR were included in the study. Patients with non-consistent symptoms of COVID-19 and those who tested negative on the PCR were excluded from the study. All clinical data, including the age of the child, the onset of symptoms, the gap between the onset of symptoms and presentation as well as clinical symptoms, were documented on a predefined proforma. Results: A total of 106 patients were enrolled on the study. The mean age of patients was 5.6±2.5 years. The most frequent symptoms were fever (63, 59.6%) and cough (49, 46.2%). There were 3(2.9%) cases with severe or critical illness. The most frequent abnormal laboratory findings were leukopenia (29, 27.4%) and increased creatine kinase (38, 36.0%). Ground-glass opacities were observed in the HRCT chest of 17(65.3%) cases, out of 26 children diagnosed with pneumonia. The majority (70, 66%), had a positive exposure history. 88(83%) cases did not abide by the precautionary measures against the COVID-19 disease. Conclusions: The current study indicates that children usually present with mild symptoms but can present as severe diseases, as observed in this study. © 2022, Army Medical College. All rights reserved.

Food and immunity: a pragmatic approach to mitigate corona viruses attack

Purpose: Corona viruses have spiked structure and enveloped glycoproteins in their structure, along with specific proteins in membranes. The mode of action of COVID-19 consists of three phases, i.e. viral replication, immune hyperactivity and pulmonary destruction. However, angiotensin-converting enzyme is an essential receptor that causes COVID-19. After infecting any individual, COVID-19 develops in specific pattern with the following stages: replication stage and adaptive immunity stage. After adaptive immunity stage, the clinical symptoms of patient include cough, fever, runny nose, shortness of breath and many more. To cope with this COVID-19, food and nutrition played an important role. The purpose of this review article is to emphasize the significance of food and immunity to reduce COVID-19 attack among susceptibles. Design/methodology/approach: In the present era, corona virus, a member of crown-shaped type, created a pandemic situation around the globe owing to its capability to move from human to animals and vice versa. This virus can transfer its 35% infection to the individuals. Contemporarily, this outbreak was observed in Wuhan, China in December 2019 and affected a huge number of communities by spreading like common flu. However, after investigation, it was revealed that COVID-19 is different from common flu regarding respiratory illness created by this novel coronavirus along with its taxonomy. Findings: Over and above to all the aforementioned food safety concerns, it is suggested to use sufficient supply of green leafy vegetables along with fiber-rich foods such as legumes, beans, whole grains and vegetables. It is further good for health to get all these varieties whole and organic. The individuals should use probiotics (lactobacillus) on daily basis as a source of diary probiotic that can further bind to the virus directly and then can inhibit the viral attachment with body cells;also the probiotics are claimed to enhance the immune system of the body. Research limitations/implications: In the case of fruits and vegetables purchased, it must be thoroughly washed with water and then disinfected;after pat drying, these fruits and vegetables can be moved to the refrigerator and stored along with other foods. During the outbreak of COVID-19, the partially cooked or ready-to-eat foods should be avoided, especially eggs, meat, meat products, milk and milk-related products. On the other side, nuts should not be consumed;if required, then it must be properly roasted at home before consumption. Practical implications: The baked product right after coming out of oven is completely safe;however, these are contaminated during handling such as crumb in case of bread and with knives;so in the breakout of any viral attack, the individuals should avoid slicing of the bread. Moreover, it is recommended to place the baked products in personal bags instead of bulk quantity. Before the consumption, the baked products should be toasted, microwaved or heated with the help of pan (traditional) to reduce the amount of viral load. Social implications: Dietary supplements are taken by most of the people on daily basis or sporadically especially when they are suffering from inflammation or cold. They have options while selecting these types of supplements such as probiotics, Echinacea, omega-3 fatty acids, vitamins D and E, calcium glucosamine, garlic and iron. These supplements are beneficial for the group of population who do not eat diversity of food as sufficient amount of essential nutrients is provided through this pathway. Originality/value: This work is original in its novelty. © 2021, Emerald Publishing Limited.

Integration of two acute paediatric services during Covid-19

Introduction To describe our experience during the COVID 19 pandemic when the acute in-patient service in CHI at Tallaght was relocated to CHI at Crumlin. Methods We describe the change management and the hospital activity across the two tertiary centres during the early pandemic (March-June 2020) and compared this to the same period in 2019. Results We compared activity during the pandemic to the same period in 2019, as the in-patient unit in Tallaght closed but day-care and OPD care continued. In CHI at Tallaght the number of day-cases and the new and review patients at ‘face to face’ OPD reduced by 76.29% (370), 67.06 % (1899) and 72.58% (2448) respectively. Similarly, in CHI at Crumlin, the admissions from ED, the day-cases, the number of new and review patients at ‘face to face’ OPD decreased by 21.74% (593), 29.14% (1442), 66.88% (2870) and 67.13% (8009) respectively. However, the number of patients managed in the virtual clinics increased significantly on both sites. All education sessions were delivered online. Conclusion With leadership, good decision making and the flexibility of clinical staff, we demonstrated how a rapid integration of services can be achieved. Whist activity levels reduced initially;new ways of working allowed us to continue to care for patients. Our shared experience was positive as we devised new team-working schedules, delivered remote education, and learned together in the midst of a crisis.

Prediction of COVID-19 Pandemic Spread in Kingdom of Saudi Arabia

A significant increase in the number of coronavirus cases can easily be noticed in most of the countries around the world. Inspite of the consistent preventive initiatives being taken to contain the spread of this virus, the unabated increase in the cases is both alarming and intriguing. The role of mathematical models in predicting and estimating the spread of the virus, and identifying various preventive factors dependencies has been found important and effective in most of the previous pandemics like Severe Acute Respiratory Syndrome (SARS) 2003. In this research work, authors have proposed the Susceptible-Infectected-Removed (SIR) model variation in order to forecast the pattern of coronavirus disease (COVID-19) spread for the upcoming eight weeks in perspective of Saudi Arabia. The study has been performed by using SIR model with a proposed simplification using average progression for further estimation of beta and gamma values for better curve fittings ratios. The predictive results of this study clearly show that under the current public health interventions, there will be an increase in the COVID-19 cases in Saudi Arabia in the next four weeks. Hence, a set of strong health primitives and precautionary measures are recommended in order to avoid and prevent the further spread of COVID-19 in Saudi Arabia.

COVID-19: Prospective Challenges and Potential Vaccines

Context . RNA viruses exhibit an extraordinary ability to evolve in a changing environment and to switch from animal hosts to humans. The ongoing COVID-19 pandemic, recognized as a respiratory disease, is an example of zoonotic transmission of the RNA virus known as SARS-CoV-2. The development and regulatory approval of a vaccine against SARS-CoV-2 pose multiple preventive and therapeutic challenges, especially during an ongoing pandemic. Objective . The review intended to examine the challenges and recent achievements in the development of vaccine candidates against COVID-19. Design . The research team performed a literature review, searching relevant and up to date information from the literature. The sources of data included Google Scholar, PubMed, NCBI, and Yahoo. The search terms used were COVID-19 challenges, SARS-CoV-2 prospective challenges, RNA viruses adoptability, host switching by RNA viruses, COVID-19 vaccines. Setting . The study took place at the digital libraries of contributing institutions. The data was combined, selected for further analysis and manuscript preparation at King Abdulaziz University. Results . RNA viruses with high rate of genome alterations and evolution have better chances to survive in the adverse environmental conditions by adopting the alternate host species. The recent epidemics such as SARS, MERS, and COVID-19 are examples of zoonotic transmission of RNA viruses from animal species to the humans. However, the mechanisms involved in the switching-on to new host species need further investigations to control the zoonotic transmissions in near future. As of April 2020, 115 candidate vaccines were being evaluated;78 of them had been found to be active, and a few of them are in Phase I trials. In the development of different types of vaccine candidates against COVID19, multiple international pharmaceutical and biotechnology companies are involved. Conclusions . Emerging and re-emerging pathogenic RNA viruses pose a serious threat to human health. Little is known about the human-host adoptive mechanism for zoonotic transmission. Deep insights into the molecular mechanism responsible for the switching of animal or bird viruses to humans could provide target molecules or events to prevent such transmissions in the near future. Fast development and approval of efficacious and safe vaccines is key to the effort to provide preventive measures against COVID-19 and future viruses. However, the development and availability of a vaccine candidate is a time-consuming process and often can't be completed during an epidemic. Currently, several types of vaccines are under development, and most of them won't realistically be available in time for the present COVID-19 pandemic.

SARS - CoV-2, Pandemic COVID 19: A Brief Review

As a novel coronavirus now known as SARS-COV-2 first reported in Wuhan china in late December 2019, the severe corona respiratory syndrome (SARS-CoV) is responsible for an acute human respiratory syndrome and is linked to Wuhan wholesale sea food market. The virus spread rapidly involving whole country and with span of three months WHO had to declare it as pandemic. Although its origins are not entirely understood, these genomic analyses suggest that SARS-CoV-2 probably evolved from a strain found in bats. SARS-COV-2 is zoonotic but human-to-human transmission is also possible. Surveillance and phylogenetic researches indicate SARS-CoV-2 to be closely associated with bats' corona viruses, suggesting bats as reservoirs, although unconfirmed. With no vaccine currently available for SARS-COV-2 nor approved prophylactics, its global spread to over 150 countries with high virulence highlights its role as ongoing public health threat. An articulated action plan ought to be taken, preferably from a One Health perspective, for appropriately advanced counter measures against COVID 19.

COVID-19: Prospective Challenges and Potential Vaccines

Context: RNA viruses exhibit an extraordinary ability to evolve in a changing environment and to switch from animal hosts to humans. The ongoing COVID-19 pandemic, recognized as a respiratory disease, is an example of zoonotic transmission of the RNA virus known as SARS-CoV-2. The development and regulatory approval of a vaccine against SARS-CoV-2 pose multiple preventive and therapeutic challenges, especially during an ongoing pandemic. Objective: The review intended to examine the challenges and recent achievements in the development of vaccine candidates against COVID-19. Design: The research team performed a literature review, searching relevant and up to date information from the literature. The sources of data included Google Scholar, PubMed, NCBI, and Yahoo. The search terms used were COVID-19 challenges, SARS-CoV-2 prospective challenges, RNA viruses adoptability, host switching by RNA viruses, COVID-19 vaccines. Setting: The study took place at the digital libraries of contributing institutions. The data was combined, selected for further analysis and manuscript preparation at King Abdulaziz University. Results: RNA viruses with high rate of genome alterations and evolution have better chances to survive in the adverse environmental conditions by adopting the alternate host species. The recent epidemics such as SARS, MERS, and COVID-19 are examples of zoonotic transmission of RNA viruses from animal species to the humans. However, the mechanisms involved in the switching-on to new host species need further investigations to control the zoonotic transmissions in near future. As of April 2020, 115 candidate vaccines were being evaluated;78 of them had been found to be active, and a few of them are in Phase I trials. In the development of different types of vaccine candidates against COVID-19, multiple international pharmaceutical and biotechnology companies are involved. Conclusions: Emerging and re-emerging pathogenic RNA viruses pose a serious threat to human health. Little is known about the human-host adoptive mechanism for zoonotic transmission. Deep insights into the molecular mechanism responsible for the switching of animal or bird viruses to humans could provide target molecules or events to prevent such transmissions in the near future. Fast development and approval of efficacious and safe vaccines is key to the effort to provide preventive measures against COVID-19 and future viruses. However, the development and availability of a vaccine candidate is a time-consuming process and often can't be completed during an epidemic. Currently, several types of vaccines are under development, and most of them won't realistically be available in time for the present COVID-19 pandemic.